- A study finds a toxic deposit of a protein called "tau" responsible for the progression of Alzheimer’s disease, supranuclear palsy, and rare brain illnesses.
- This new research was conducted at the University of Texas Health Science Center, where scientists discovered an inflammatory trigger that is similar to the one found in viral infections.
- The research found the tau-induced "jumping genes" relocate and copy themselves to different locations in the genome and form double-stranded RNA.
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- The experiment detected an accumulation of double-stranded RNA in the postmortem brain tissue of patients with Alzheimer’s disease, and the findings were published in Science Advances.
- They found a substantial deposit of double-stranded RNA in astrocytes (cells that provide metabolic support for neurons). Astrocytes respond to injury and disruption of the neuronal environment when the research was performed on the brains of mice and fruit flies (model of tauopathy).
- Identification of new triggers of brain inflammation disorders is helping target jumping gene activation in local phase 2 clinical trials for patients with Alzheimer’s disease.
- These new findings will help researchers better understand astrocyte biology and its role in transposable element control.
Source- ET Healthworld
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