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Cancer is a global concern, accounting for millions of deaths despite having various treatments available.
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A University of Tokyo research group led by assistant professor Kunihiko Morihiro and professor Akimitsu Okamoto, created a new anticancer drug using artificial DNA.
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Researchers have found a novel method of creating artificial DNA in labs that can now trace and help eliminate cancerous cells from the body.
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The team created artificial oncolytic (cancer-killing) DNA hairpin pairs called oHPs.
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This method has been tested effectively against human cervical cancer cells, human breast cancer cells, and mouse malignant melanoma.
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A cancer-curing, hairpin-shaped DNA molecule pair was given to the group of people using chemical synthesis. These DNA pairs got linked to miRNA molecules that were overproduced by some tumours when injected into cancer cells.
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These DNA pairs get to unwind and combine to produce longer DNA chains. When confronted with the mRNA miR-21, OHPs are stimulated to form longer DNA strands.
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This new approach that differs from traditional anticancer drug therapies was found to eliminate the cancer cells from the body and also stop the spread of malignant tissues.
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This research study will significantly bring in a new era of cancer drugs. The drugs based on nucleic acids such as DNA and RNA are expected to transform medicine and treatment for cancer.
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"The results of this study are good news for doctors, drug discovery researchers, and cancer patients, as we believe they will give them new options for drug development and medication policies." Professor Okamoto, a researcher at the Graduate School of Engineering, agrees.
Source: ET Healthworld