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According to new research, aggressive surgical removal of brain tumours can slow tumour growth.
UC San Francisco led this study and published it in the journal 'Clinical Oncology'.
The research was conducted on 392 patients with low-grade glioma for up to 20 years.
The study findings contradicted previous research that claimed maximum surgical removal was not required to slow down the resection but the tumour characteristics. Thus, the study recommends that neurosurgeons remove as many tumours as possible soon after diagnosis.
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Brain tumours are diffusive in nature, and undetectable pockets of tumour cells grow slowly after resection. This leads to recurrence and eventually to malignant tumours that cause death.
Research suggested that patients with major post-operative astrocytomas had a median survival time of nine years after diagnosis as compared to 20 years of living with people having small residual tumours.
Also, the median survival time of 19.9 years for patients with post-operative oligodendrogliomas as compared to 20 years of living with smaller residual tumours.
The researchers found patients who had undergone a potentially riskier procedure, gross total resection (GTR), in which all visible tumours (detected on an MRI) were removed, lived longer than those with residual tumours left inside.
"We found that resecting as much as possible soon after diagnosis offered a distinct survival advantage when we looked at the disease trajectory 10 years later," says co-senior author Annette Molinaro, PhD, a professor in the UCSF Department of Neurosurgical Surgery.
The debate concerning whether or not all low-grade gliomas require maximal excision has been resolved as a result of these findings.
Source- ET Healthworld
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