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Allogeneic Bone Marrow Transplant and Cost in India

  • Cost of Allogeneic BMT in India varies from USD 22000 to USD 25000.
  • Patient has to spend around 21 days in hospital and 90 days outside the hospital.
  • The first year after Allogeneic Bone Marrow Transplant is critically important because it’s the period when complications like Graft-Versus-Host Disease (GVHD) and others can arise.
  • Tests required prior to Allogeneic BMT are Blood Tests, Bone Marrow Biopsy, Dental X-Ray, Chest X-Ray, Electrocardiogram (ECG), RVG and PFTs.

Allogeneic Bone Marrow Transplant and Cost in India

 

  • Cost of Allogeneic BMT in India varies from USD 22000 to USD 25000.
  • Patient has to spend around 21 days in hospital and 90 days outside the hospital.
  • The first year after Allogeneic Bone Marrow Transplant is critically important because it’s the period when complications like Graft-Versus-Host Disease (GVHD) and others can arise.
  • Tests required prior to Allogeneic BMT are Blood Tests, Bone Marrow Biopsy, Dental X-Ray, Chest X-Ray, Electrocardiogram (ECG), RVG and PFTs.

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Allogeneic Bone Marrow Transplant Cost In India

For A Patient From Germany

Allogeneic Bone Marrow Transplant Price USD 22,000 No. of Travellers 2 Days in Hospital 21 Days Outside Hospital 90 Total days in India 111

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Top Doctors For Allogeneic Bone Marrow Transplant Treatment in India View all (16)

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Selected :
Doctor for Allogeneic Bone Marrow Transplant - Dr. TPR Bharadwaj

Dr. TPR Bharadwaj

Hematologist

43 years of experience , Chennai

Doctor for Allogeneic Bone Marrow Transplant - Dr. Anil Handoo

Dr. Anil Handoo

Hematologist

10 years of experience , New Delhi

Doctor for Allogeneic Bone Marrow Transplant - Dr. Srikanth M

Dr. Srikanth M

Hematologist

21 years of experience , Chennai

Doctor for Allogeneic Bone Marrow Transplant - Dr. Manas Kalra

Dr. Manas Kalra

Hematologist

13 years of experience , New Delhi

Top Hospitals For Allogeneic Bone Marrow Transplant Treatment in India View all (53)

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More About Allogenic bone marrow transplant

Types of bone marrow transplant / Stem cell Transplant

Autologous transplant - When the stem cells come from your own blood or bone marrow, it is called an autologous transplant

Allogenic transplant - When the stem cells come from another person, it is called an allogeneic transplant. The donor's immune system markers are closely matched to recipient. The donor may be a relative or a complete stranger.

 

Bone marrow transplant can be used  in :

  • In diseases such as leukaemia , aplastic anaemia , sickle cell anaemia , non-Hodgkin's lymphoma and Hodgkin's lymphoma, multiple myeloma, and aplastic anemia etc

  • Restore bone marrow that has been damaged after cancer treatment by total body radiation and high doses of chemotherapy .

  • Regenerate a new immune system that will fight existing  cancers not killed by chemotherapy or radiation

  • As the treatment of immune system  and genetic defects, diabetes, sickle cell disease, and thalassemia, autism etc

 

Stem cells Collection Procedure

Stem cells for transplantation are collected from either :

  • Blood

  • Bone marrow

  • Placental and umbilical cord blood

 

Blood :

  • For peripheral blood stem cell transplantation (PBSCT), stem cells are taken from blood.

  • The growth factor G-CSF is used to stimulate the growth of new stem cells

  • The blood is removed  and passed through a machine that takes out the stem Cells and  circulates the remaining blood back to the donor . This way of collecting stem cells is called apheresis.

 

Bone marrow :

  •  Stem cells can be  retrieved  directly from the bone marrow.

  • This requires the donor to undergo a minor surgical procedure.

  • The surgeon inserts a hollow needle into the donor's pelvic bones  and removes liquid marrow. This is done many times to collect enough stem cells for the person receiving the donated bone marrow, is called harvesting the bone marrow .

  • The marrow that's removed (harvested) passes through a series of filters to remove bone or tissue fragments and is then placed in a blood  bag from which it can be infused into the recipient. 

 

Placental and  cord blood :

Stem cells may also be taken from umbilical cord blood.

Transplant Proedure:

Before Transplant :- Before you have a transplant, you physician will discuss the transplant process and all its effects with you.

You will first be evaluated to find out if you are eligible for a transplant.

Many different medical tests will be performed , these might include:

  • HLA tissue typing

  • A complete health history and physical exam

  • Bone marrow biopsy

  • CT (computed tomography) scan or MRI (magnetic resonance imaging)

  • Heart tests

  • Lung function tests, such as a chest x-ray and PFTs

  • Blood tests, such as a complete blood count, blood chemistry ,  hepatitis B, CMV, and HIV

 

Conditioning treatment (chemo and/or radiation therapy)

  • It’s the first step in the transplant process and typically takes a week or two.

  • Conditioning is treatment with high-dose chemo and/or radiation therapy.

  • Doctors use chemotherapy and radiation to destroy bone marrow. This also gets rid of the cancer cells-along with the normal cells-in your bone marrow and the rest of your body. Later, when  healthy stem cells are infused from a donor, those new cells will go to the marrow and be able to take over the job of making new blood cells

  • This phase of the transplant can be very uncomfortable because very high treatment doses are used. Chemo and radiation have many  side effects .

 

Infusion of stem cells

  • A central venous catheter (CVC) is inserted  , the CVC will stay in during your treatment and for some time afterward until  your blood counts are normal.

  • After few days after conditioning treatment, you will  be transfused stem cells. They will be given through your central venous catheter, much like a blood transfusion.

  • For allogeneic  transplants, the donor cells may be removed  and then processed in the lab right away  and transfused to recipient  – they’re not frozen.

  • It is a painless process and no anesthesia required.

  • Side effects from the infusion are rare and usually mild, If they do happen, they are treated as needed. The stem cell infusion must always be completed.

 

Some side effects may be

  • Fever or chills

  • Shortness of breath

  • Hives

  • pain , Tightness in the chest

 After Infusion

  • The recovery stage begins after the stem cell infusion.

  • The time taken  for normal blood counts is usually about 2 to 6 weeks but varies from individual patient

  • Right after transplant,the blood  counts are the lowest,  prophylactic antibiotics are given  to prevent  from getting infections.

  • Still, many patients have high fevers  due to very  few white blood cells (neutropenia), or bleeding from too few platelets (thrombocytopenia).

  • Transfusions of RBCs and platelets are often needed until the bone marrow starts working and new blood cells are being made by the infused stem cells

 Risks Of Transplant

  • Infections

  • Graft failure. The new stem cells do not work,

  • Graft-versus-host disease- The new stem cells attack other cells in your body.

  • Veno-occlusive disease- liver pathology caused by the high dose of chemotherapy or radiation given before a transplant.

 

Factors Affecting Cost Of Transplant

The cost to the patient depends on a variety of factors like

  • The hospital, the patient chooses.

  • Room –Standard single room, deluxe room, super deluxe room for the number of nights specified (including nursing fee, meals, room rate, and room service).

  • Fee for the team of doctors

  • cost of  medications, immunosuppressant drugs ,  chemo/ radiotherapy 

  • cost for stem cell collection process n donor testing

  • Standard tests and procedure for the recipient

  • Cost of the follow –up care required after the procedure

 

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